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Titlebook: Early Life Origins of Ageing and Longevity; Alexander Vaiserman Book 2019 Springer Nature Switzerland AG 2019 Developmental programming.Ag

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Immunological Basis of In Utero Programming of Adult Diseaseal corticosteroids and intrauterine growth restriction (IUGR), pups are born with low birth weights and develop type 2 diabetes (T2D) as adults. In the IUGR model, development of T2D is dependent on interleukin 4 in the neonatal period. Development of the fetal immune system has the potential to eff
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Early Life Nutritional Programming of Adult Health Statussk of poor adult cardiovascular and metabolic health. However, in contemporary Western societies, maternal over-nutrition, overweight and obesity are far more common nutritional issues and this has led to an increased focus of the field on the long-term consequences of exposure to these stimuli in e
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The Interplay Between Dopamine and Environment as the Biological Basis for the Early Origins of Mentrly life adversity. These neurons regulate cognitive-emotional states, notably impulsivity, and reward-based decision-making, thus defining psychiatric phenotypes and contributing to intensify behaviors that in turn promote metabolic disturbances. We will also apply the concept of differential susce
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Nutrigenomics as a Strategy for Neuronal Healthoff of genes. An anti-inflammatory diet during early-life and across the whole life may represent a key strategy for influencing brain plasticity and for building an “epigenetic memory” useful in developing neuronal resilience against early-life stressors and to prevent age-related neurodegeneration
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Why Is Parental Lifespan Linked to Children’s Chances of Reaching a High Age? A Transgenerational Hyhters compared to mothers. Parents’ and maternal grandmother’s longevity were associated with resilience in subsequent generations. Resilience scores of G2 men were also associated with those of their G3 sons and with their own mortality in midlife. We conclude that chances of reaching a high age ar
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Influence of Maternal Obesity on the Long-Term Health of Offspring
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