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Titlebook: Early Life Origins of Ageing and Longevity; Alexander Vaiserman Book 2019 Springer Nature Switzerland AG 2019 Developmental programming.Ag

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书目名称Early Life Origins of Ageing and Longevity
编辑Alexander Vaiserman
视频video
概述Gathers recent research on developmental programming and age-related disease.Expert contributors describe the developmental origins of adult health and disease.Benefits gerontology scholars, researche
丛书名称Healthy Ageing and Longevity
图书封面Titlebook: Early Life Origins of Ageing and Longevity;  Alexander Vaiserman Book 2019 Springer Nature Switzerland AG 2019 Developmental programming.Ag
描述.This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. .While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process..Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical .in-utero. and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. .In this book, the contributing authors and leading experts from around the world, descr
出版日期Book 2019
关键词Developmental programming; Aging; Age-related disease; Longevity; Epigenetics; biogerontology; gene expres
版次1
doihttps://doi.org/10.1007/978-3-030-24958-8
isbn_softcover978-3-030-24960-1
isbn_ebook978-3-030-24958-8Series ISSN 2199-9007 Series E-ISSN 2199-9015
issn_series 2199-9007
copyrightSpringer Nature Switzerland AG 2019
The information of publication is updating

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laboratory stocks of mice, genetic GH deficiency or resistance led to remarkable extension of healthspan and longevity. In GH-deficient Ames dwarf mice a brief period of GH replacement therapy normalizes (“rescues”) many adult aging-related traits and shortens longevity. This indicates that absence
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https://doi.org/10.1057/9780230390218Dutch famine showed that babies with low birth weights had significantly higher obesity rates as adults. In several other studies, low birth weight has been correlated with development of type 2 diabetes (T2D), cardiovascular disease and obesity. Maternal diseases, such as hypertension and gestation
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The Making of the Twentieth Centuryhe lifecourse and evidence for transmission of these adverse disease traits to future generations. A key component underpinning this early life developmental programming is that of dysregulation of the growth hormone-insulin-like growth factor (GH-IGF) axis. Phenotypic outcomes in programmed offspri
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