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Titlebook: Drug‘DNA Interaction Protocols; Keith R. Fox Book 19971st edition Humana Press 1997

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The Ins and Outs of the Third Dimension interactions frequently involve a reversible mechanism, a determination of the equilibrium binding constant can provide insight into the nature and strength of the underlying intermolecular events. Analysis of the induced spectral effects can also reveal considerable detail about the host-drug stoi
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measurements both (.) the affinity (ΔG) and enthalpy change (ΔH) for the process. There are, however, many sites on the DNA lattice for interactions and assigning AH values for each IS dependent on the model used in the mathematical analysis. What can be obtained in most cases from careful calorimet
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DNase I Footprinting, the technique was developed in 1978 for studying the interaction of DNA-binding proteins with then target sites (.), it has proved invaluable for determining the sequence specificity of many small ligands
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Analysis of DNA-Binding Antibodies,e, but they are involved in the pathogenesls of the disease through the formation of immune complexes that indirectly cause tissue damage. Alternatively, the antibodies may crossreact with cell surface antigens and cause tissue damage directly. Thus, understanding the specificity of autounmune antibodies is important.
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