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Titlebook: Drug‘DNA Interaction Protocols; Keith R. Fox Book 19971st edition Humana Press 1997

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发表于 2025-3-21 16:56:46 | 显示全部楼层 |阅读模式
书目名称Drug‘DNA Interaction Protocols
编辑Keith R. Fox
视频video
丛书名称Methods in Molecular Biology
图书封面Titlebook: Drug‘DNA Interaction Protocols;  Keith R. Fox Book 19971st edition Humana Press 1997
描述In Drug-DNA Interactions, expert researchers describe powerful molecular techniques designed to illuminate and explore the interaction of drugs and ligands with DNA, often perfected in their own laboratories, . These easily reproducible methods involve sequence recognition properties, as well as physical approaches to measuring both the strength of interaction and the mode ofdrug binding to DNA. Drug interactions are also examined from a cellular perspective and for their usefulness in the development of new therapeutic agents. ..Drug-DNA Interactions will be highly useful to all investigators needing the kind of detailed experimental and technical information often omitted from scientific papers. Those wishing to expand their repertoire of experimental techniques or to improve their current techniques will also find these powerful methods particularly helpful in elucidating the action of existing therapeutic agents, as well as in designing new anticancer drugs with improved action and reduced toxicity. .......
出版日期Book 19971st edition
版次1
doihttps://doi.org/10.1385/089603447X
isbn_ebook978-1-59259-574-7Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightHumana Press 1997
The information of publication is updating

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发表于 2025-3-21 22:25:08 | 显示全部楼层
The Ins and Outs of the Third DimensionA large category of anticancer drugs owe their cytotoxicity to their abihty to Interact with, and damage, DNA. Many agents form bulky adducts that block RNA and DNA polymerases, inhibiting transcription, and DNA rephcation.
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New Window on the World with OpenGL ESe, but they are involved in the pathogenesls of the disease through the formation of immune complexes that indirectly cause tissue damage. Alternatively, the antibodies may crossreact with cell surface antigens and cause tissue damage directly. Thus, understanding the specificity of autounmune antibodies is important.
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Strong, Em, and Other Phrase Elements the technique was developed in 1978 for studying the interaction of DNA-binding proteins with then target sites (.), it has proved invaluable for determining the sequence specificity of many small ligands
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