Titlebook: Drug Targets in Kinetoplastid Parasites; Hemanta K. Majumder Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive li

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Fishing for Anti-Leishmania Drugs: Principles and Problems,. Current drugs are toxic and expensive, and are losing their effectiveness due to parasite resistance. The availability of the genome sequence of two species of .and ., as well as that of . and . should provide a cornucopia of potential new drug targets. Their exploitation will require a multi-disc

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Sterol 14-Demethylase Inhibitors for , Infections,dic compounds (benznidazole and nifurtimox) that are suboptimal due to poor curative activity for chronic Chagas disease and high rates of adverse drug reactions. Sterol 14-demethylase inhibitors include azole antifungal drugs such as ketoconazole, fluconazole, itraconazole, and others. The first re

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Targeting Glycoproteins or Glycolipids and Their Metabolic Pathways for Antiparasite Therapy,nfections more efficiently and effectively. Targeting novel glycoproteins/lipids, which are important disease determinants of kinetoplastid diseases, have helped in the development of this field. Better and refined understanding of all the available data would possibly help us in providing a future

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DNA Topoisomerases of ,: The Potential Targets for Anti-Leishmanial Therapy,resulting from morbidity, primarily in the tropical and subtropical areas. This ancient eukaryote shows variable genetic diversity in their life cycle, wherein DNA topoisomerases play a key role in cellular processes affecting the topology and organization of intracellular DNA. Kinetoplastid topoiso

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Searching the Tritryp Genomes for Drug Targets, are common to all three genomes, and ushers in a new, post-genomic, era for trypanosomatid drug discovery. This vast amount of new information makes possible more comprehensive and accurate target identification using several new computational approaches, including identification of metabolic “chok

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Purine and Pyrimidine Metabolism in ,,rgy, cAMP and cGMP are key second messenger molecules, purine and pyrimidine nucleotides are precursors for activated forms of both carbohydrates and lipids, nucleotide derivatives of vitamins are essential cofactors in metabolic processes, and nucleoside triphosphates are the immediate precursors f

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