Titlebook: Drug Targets in Kinetoplastid Parasites; Hemanta K. Majumder Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive li

GAVEL

gy. Therefore, understanding the biology of kinetoplastid topoisomerases and the components and steps involved in this intricate process provide opportunities for target based drug designing against protozoan parasitic diseases.

micronutrients

Unique Characteristics of the Kinetoplast DNA Replication Machinery Provide Potential Drug Targets cation of free detached minicircles and catenated maxicircles, and the generation of two progeny kDNA networks. It is catalyzed by an enzymatic machinery, consisting of kDNA replication proteins that are located at defined sites flanking the kDNA disk in the mitochondrial matrix (for recent reviews on kDNA see refs. 1-8).

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Fishing for Anti-Leishmania Drugs: Principles and Problems,iplinary approach that includes protein structure and function and high throughput screening of random and directed chemical libraries, followed by in vivo testing in animals and humans. We outline the opportunities that are made possible by recent technologies, and potential problems that need to be overcome.

鼓掌

紧张过度

Antiparasitic Chemotherapy:,fects is therefore of primary importance. Like most parasitic protozoan, the genus . is an obligate auxotroph of purines and hence for requirement of purine bases depends on its own purine salvage pathways.

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impaction

Purine and Pyrimidine Metabolism in ,, small complement of pyrimidine salvage enzymes. Because the pyrimidine nucleotide biosynthetic pathways of . and humans are similar, pyrimidine metabolism in . has generally been considered less amenable to therapeutic manipulation than the purine salvage pathway. However, evidence garnered from a