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Titlebook: Drug Targets in Kinetoplastid Parasites; Hemanta K. Majumder Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive li

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发表于 2025-3-21 16:58:00 | 显示全部楼层 |阅读模式
书目名称Drug Targets in Kinetoplastid Parasites
编辑Hemanta K. Majumder
视频video
丛书名称Advances in Experimental Medicine and Biology
图书封面Titlebook: Drug Targets in Kinetoplastid Parasites;  Hemanta K. Majumder Book 2008 The Editor(s) (if applicable) and The Author(s), under exclusive li
描述.If viewed globally, the parasitic diseases pose an increasing threat to human health and welfare. The diseases caused by kinetoplastid protozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas’ disease is endemic in Latin America, while members of Trypanosoma brucei group are found in sub-Saharan Africa. Although the past two decades has witnessed commendable research efforts and technical advances in our understanding of the biochemistry, molecular and cell biology of these pathogens, the dreaded protozoal diseases caused by these organisms threaten mankind. Therapeutic tools for the treatment of most parasitic diseases are extremely limited. The development of parasites resistant to many of the available drugs is also responsible for the depressing picture of disease persistence and death. Development of commercially available vaccines is still far from reality, though research and trial programs continue. .
出版日期Book 2008
关键词biochemistry; cell; chemistry; death; development; diseases; genome; health; metabolism; parasite; parasites; p
版次1
doihttps://doi.org/10.1007/978-0-387-77570-8
isbn_softcover978-1-4419-2656-2
isbn_ebook978-0-387-77570-8Series ISSN 0065-2598 Series E-ISSN 2214-8019
issn_series 0065-2598
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Busines
The information of publication is updating

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发表于 2025-3-21 22:03:25 | 显示全部楼层
Selective Lead Compounds against Kinetoplastid Tubulin,ments against cancer and helminths, suggesting that kinetoplastid tubulin is also a suitable target for antiprotozoal compounds. Selective lead compounds against kinetoplastid tubulin have been identified that could represent a starting point for the development of new drug candidates against these parasites.
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Wave Propagation in Infinite Domainsiplinary approach that includes protein structure and function and high throughput screening of random and directed chemical libraries, followed by in vivo testing in animals and humans. We outline the opportunities that are made possible by recent technologies, and potential problems that need to be overcome.
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0065-2598 ozoan parasites like Leishmania and Trypanosoma continue as a cause of suffering for many millions of people in both tropical and subtropical regions of the world. Leishmania species are found throughout Latin America, Africa and Asia. Trypanosoma cruzi that cause Chagas’ disease is endemic in Latin
发表于 2025-3-23 03:24:21 | 显示全部楼层
Offshore wind energy conversion systemsments against cancer and helminths, suggesting that kinetoplastid tubulin is also a suitable target for antiprotozoal compounds. Selective lead compounds against kinetoplastid tubulin have been identified that could represent a starting point for the development of new drug candidates against these parasites.
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Begriff und Ziele des Wettbewerbsrechtscation of free detached minicircles and catenated maxicircles, and the generation of two progeny kDNA networks. It is catalyzed by an enzymatic machinery, consisting of kDNA replication proteins that are located at defined sites flanking the kDNA disk in the mitochondrial matrix (for recent reviews on kDNA see refs. 1-8).
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