Titlebook: Death Receptors in Cancer Therapy; Wafik S. El-Deiry Book 2005 Humana Press 2005 TNF.apoptosis.carcinoma.cell.cell death.gene therapy.inte

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L. M. L. Tuyt,W. H. A. Dokter,E. Vellengad resistance, and strategies to enhance sensitivity or overcome resistance have been devised. In this chapter the role, function, and regulation of the death receptor signaling pathway inhibitors, how they can be targeted therapeutically, and the implications for future cancer therapies will be disc

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Institution

Resistance to Apoptosis in Cancer Therapy,se. Parallel efforts have defined the evolutionarily conserved components of the apoptotic pathway, inspiring efforts to characterize the functional status of these components in human tumor cells. Although core pathway defects have been documented, the apoptotic pathway appears to be intact in most

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Structures of TNF Receptors and Their Interactions With Ligands, apoptosis, modulation of the immune system, and regulation of developmental pathways in some tissue types. Some TNFRs positively regulate cell growth, whereas others initiate apoptotic pathways upon stimulation by ligand (.). These contradictory biological activities are determined to some extent b

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Death Receptor Signaling in Embryonic Ectodermal Development,o derivatives of ectoderm (e.g., skin, nails, sweat glands, or teeth) (.). More than 150 different types of EDs have been identified, and the combined incidence of these disorders may be as high as 7 per 10,000 births. However, a large number of cases go undetected due to the relatively mild phenoty

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Adaptor Proteins in Death Receptor Signaling,ch for the past several years. The major advances arising from these studies have been the characterization of critical signal-transducing adaptor molecules and the delineation of parallel but opposing signaling pathways, some inducing apoptosis and others promoting cell survival. An imbalance in fa

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Overdose