Titlebook: Death Receptors in Cancer Therapy; Wafik S. El-Deiry Book 2005 Humana Press 2005 TNF.apoptosis.carcinoma.cell.cell death.gene therapy.inte

fatty-streak

Sensitizing Tumor Cells by Targeting Death Receptor Signaling Inhibitors,d resistance, and strategies to enhance sensitivity or overcome resistance have been devised. In this chapter the role, function, and regulation of the death receptor signaling pathway inhibitors, how they can be targeted therapeutically, and the implications for future cancer therapies will be disc

NEX

衰老

Randy Q. Cron,Edward M. Behrensn the absence or presence of sweat gland function—hidrotic ectodermal dysplasia (or Clouston syndrome) and hypohidrotic ectodermal dysplasias (HEDs). Recent studies suggest an important role of signaling via the tumor necrosis factor receptor (TNFR) family in the pathogenesis of hypohidrotic ectoder

encomiast

CHAR

https://doi.org/10.1007/978-1-59259-129-9lysis has revealed a core apoptotic program in . comprised of three genes: CED-3, CED-4, and CED-9, with the first two promoting apoptosis and the latter inhibiting it. Epistatic analysis has identified CED-3 as the most downstream component of this program, suggesting that the functions of CED-4 an

Nerve-Block

Laurence Arbibe,Philippe Sansonettianoma lines by culture in TRAIL was also associated with decreased expression of TRAIL-R2 protein, but TRAIL-R2 mRNA levels were similar to those in parental high-TRAIL-R2 expressing cells. The latter model was used to explore post-transcriptional regulation of TRAIL-R2. Expression from a luciferase

Lamina

Michael S. Rolph,Stefan H. E. Kaufmannrnal symmetry. The consensus DNA sequence for p53 binding is 5′-PuPuPuC(A/T-A/T)GPyPyPy- N(0-13)-PuPuPuC(A/T-A/T)GPyPyPy-3′, with the third C and seventh G being highly conserved in the 10-base-pair half-sites (.). Identification of transcriptional targets of p53 has been critical in dissecting path

cavity

基因组

Arne von Bonin,Solveig H. Moré,Minka Breloerignaling by mechanisms that remain poorly understood. Interestingly, a number of recent reports suggest that a key to the success of TRAIL in cancer therapy is to use it in conjunction with chemo- or radiotherapy. Such a concept of combination therapy is gaining ground in eliminating tumors that are

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