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Titlebook: Cyclic Peptide Design; Gilles Goetz Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Drug design.Small molecul

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发表于 2025-3-21 18:53:59 | 显示全部楼层 |阅读模式
书目名称Cyclic Peptide Design
编辑Gilles Goetz
视频video
概述Includes cutting-edge techniques.Provides detail essential for successful results.Contains key advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: Cyclic Peptide Design;  Gilles Goetz Book 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 Drug design.Small molecul
描述This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature’s cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the .Methods in Molecular Biology. series, this collection includes the kind of detail and implementation advice to aid researchers in the field. .Authoritative and cutting-edge, .Cyclic Peptide Design. serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields..
出版日期Book 2019
关键词Drug design; Small molecules; Natural product chemistry; Helical peptides; Cell permeability; Protein-pro
版次1
doihttps://doi.org/10.1007/978-1-4939-9504-2
isbn_softcover978-1-4939-9506-6
isbn_ebook978-1-4939-9504-2Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2019
The information of publication is updating

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Methods in Molecular Biologyhttp://image.papertrans.cn/d/image/241990.jpg
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Studies in Systems, Decision and Controlbeyond the traditional “Rule-of-5” chemistry space (Lipinski et al., Adv Drug Deliv Rev. 23(1): 3–25, 1997). An important component of meeting this challenge is to design cyclic peptides with good intestinal permeability. Here we discuss the design principles for intestinal permeability that have be
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https://doi.org/10.1007/978-3-030-21927-7leading to the defined 3-D orientation of the constituent amino acids (pharmacophore). Although they are attractive candidates for lead discovery owing to the unique conformational features, their peptidic backbone is susceptible to proteolytic cleavage in various biological fluids that compromise t
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AC Microgrid Seamless Transitionorated into cyclic peptides (CPs), many primary peptide structures and functions are markedly altered by cyclization. Accordingly, to mimic linear peptide interfaces with cyclic peptides, it can be beneficial to screen combinatorial cyclic peptide libraries. Computational methods have been developed
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https://doi.org/10.1007/978-3-319-45735-2se of copper-catalyzed [3 + 2] azide–alkyne cycloaddition (CuAAC), better known as “click reaction” in the design and synthesis of cyclic peptide and cyclic peptidomimetic compounds. The usage of “click chemistry” reactions includes various topics: (a) mimicking peptide bonds; (b) synthesis of order
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