Titlebook: Cushing’s Syndrome; Dorothy T. Krieger Book 1982 Springer-Verlag Berlin, Heidelberg 1982 ACTH.Cushing-Syndrom.Gonadotropin.aldosterone.bio

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https://doi.org/10.1057/9780230598904recovery at the pituitary level takes a longer time than does that of adrenal responsiveness to ACTH, and the excess Cortisol secretion engendered by such ACTH administration might further delay pituitary recovery.

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,Treatment of Cushing’s Disease and Syndrome,recovery at the pituitary level takes a longer time than does that of adrenal responsiveness to ACTH, and the excess Cortisol secretion engendered by such ACTH administration might further delay pituitary recovery.

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0077-1015 ry. We owe these advances to the felicitous cooperative efforts of the clinical investigator and the biochemist. Three centuries elapsed between the first recorded anatomical descrip­ tion of the adrenals and the demonstration by Dr. Addison in the mid-nineteenth century of the fatal results of the

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,Brief Introduction to Cushing’s Syndrome and Disease,tain.” Cushing’s description of the disease included all of those physical features which today we recognize as being classical. It is also of interest that a follow-up of the patient over a period of 22 years following the onset of the disease noted her to be in “reasonably good health, though some of the stigmata of her malady still persist.”

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Physiology of Regulation of ACTH Secretion,biological steroidogenic activity equivalent to that of the ACTH. molecule. There is a marked loss of steroidogenic potency with sequences smaller than ACTH.. The duration of action is also diminished by deletion of COOH terminal sequences (Schwyzer 1964).

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Actions of Adrenocortical Hormones,corticoid actions (Baxter and Forsham 1972). It is believed that both the catabolic and anabolic responses seen with corticosteroid administration reflect the expression of similar mechanisms in different tissues (Leung and Munck 1975).