Titlebook: Cushing’s Syndrome; Dorothy T. Krieger Book 1982 Springer-Verlag Berlin, Heidelberg 1982 ACTH.Cushing-Syndrom.Gonadotropin.aldosterone.bio

DOTE

pericardium

Book 1982 these advances to the felicitous cooperative efforts of the clinical investigator and the biochemist. Three centuries elapsed between the first recorded anatomical descrip­ tion of the adrenals and the demonstration by Dr. Addison in the mid-nineteenth century of the fatal results of the destructio

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Physiology of Regulation of ACTH Secretion,mulates the adrenal cortex in vertebrate animals and man. The N-terminal 24 amino acids are identical in all species studied. Minor species differences in amino acid composition occur in the 25–39 portion of the molecule. On a molar basis, the 1–24 amino acid sequence of the ACTH molecule possesses

BAIT

PLAYS

Actions of Adrenocortical Hormones,icoid hormones., since, in cases of Cushing’s disease and syndrome, glucocorticoid concentrations may rise well into the pharmacological range (Table 4.1). These hormones affect virtually all body tissues. In recent years, investigators have sought to establish a common basic mechanism for all gluco

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dictator

,Laboratory Diagnosis of Cushing’s Disease and Syndrome,ish those who may have suggestive signs and symptoms, but may prove to be eucorticoid, from those patients who actually have increased corticosteroid production. In the latter group, it is further necessary to distinguish patients with Cushing’s disease from those with either adrenal or ectopic ACTH

Etymology

,Treatment of Cushing’s Disease and Syndrome,ociated atrophy of the contralateral adrenal, patients will require postoperative replacement therapy for a variable time period (3–18 months) until normal adrenocortical function is regained. Cortisol replacement therapy should be maintained at a sufficient dose to avoid symptoms of hypoadrenalism