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Titlebook: Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity; Frederick C. Kauffman (Director) Book 1994 Springer-Verlag Berlin Hei

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Regulation of Expression of Rat Liver Glutathione S-Transferases: Xenobiotic and Antioxidant Inducti electrophiles, the GSTs bind with high affinity a variety of hydrophobic compounds such as heme, bilirubin, polycyclic hydrocarbons, and dexamethazone (L. et al. 1971; A. et al. 1976; B. et al. 1980; H. a n d L. 1985).
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Cofactor Supply as a Rate-Limiting Determinant of Hepatic Conjugation Reactionsin Chaps. 13 and 16 of this volume). Because of the important role of transferases in catalyzing conjugation reactions, these enzymes have been studied extensively, and the properties of the important conjugating enzymes are described in Chaps. 1–7.
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Regulation of Drug Conjugate Production by Futile Cycling in Intact Cellsates across various cellular membranes, and the formation and release of conjugated products (D.V. et al. 1985) as well as the activities of transferases and hydrolases (D.V. et al. 1985; E. M. and K. 1986; S. et al. 1975).
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Health Anxiety and Somatization in Children to preventing accumulation of lipid-soluble compounds, “xenobiotic” or drugmetabolizing enzymes may also fulfill important roles in controlling endogenous signal compounds such as hormones (N. 1991).
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Treatment: What Are the Choices? esters (also variously called sulfates, or sulfooxy or sulfonyloxy derivatives) or sulfamides (sulfamates). Sulfate transfer is apparently unknown in biology. Were it to occur, the products in most cases would be peroxysulfates. We suggest that “sulfonation” be used to describe the conjugation of substrates by sulfotransferases and PAPS.
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0171-2004 logy and toxicology. This volume is an up-to-date source of information on this topic and will be of broad interest to pharmacologists and toxicologists.978-3-642-78431-6978-3-642-78429-3Series ISSN 0171-2004 Series E-ISSN 1865-0325
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