Titlebook: Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity; Frederick C. Kauffman (Director) Book 1994 Springer-Verlag Berlin Hei

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BARB

https://doi.org/10.1007/978-3-8349-9875-0y all these enzymes, i.e., .-adenosyl-.-methionine (AdoMet). The .-methylation (T. and C. 1990; B. et al. 1990; C. 1993; K. et al. 1992), .-methylation (A. and J. 1990), and S-methylation (S. and B. 1990; H. 1993) reactions have been discussed in recent comprehensive reviews.

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History of the Personal Involvement Taboo87, 1989; B. et al. 1989) and transport (B. et al. 1989; M. et al. 1990), together with clearance modifiers, such as organ blood flow, drug and conjugate binding to vascular proteins, transmembrane clearance, and the .. and .. of the saturable eliminatory pathways (for reviews, see G. and G. 1984; P

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Disciplined Personal Involvement the basolateral domain to be excreted in the urine? Is this determined by the presence and substrate specificity of transporters in each membrane domain? How are drug conjugates which are formed in other tissues, such as the intestine, taken up by the liver? Recent advances have provided answers to

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AROMA

Health Anxiety and Somatization in Childrenin urine as the corresponding mercapturic acid, which are S-conjugates of .-acetylcysteine. Conjugation with GSH has usually been considered a detoxication reaction. The increased water solubility and the active secretion of organic acids by renal tubules greatly facilitates mercapturic acid excreti

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Sulfotransferase Enzymesncreases the water solubility of most compounds and, therefore, their renal excretion. It also usually results in a decrease in biological activity, but, in some cases, sulfate conjugation is required to “activate” drugs such as the antihypertensive medication minoxidil (J. et al. 1982; M. et al. 19

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ingrate

Human ,-Acetyltransferasesug (reviewed in W. 1987). Isoniazid was a remarkably effective therapeutic agent, but, despite its effectiveness, a high proportion (3.5%–17%) of treated patients developed a devastating, progressive nerve toxicity. Pharmacokinetic studies of isoniazid elimination in twins and in families revealed s