Titlebook: Congenital Heart Diseases: The Broken Heart; Clinical Features, H Silke Rickert-Sperling,Robert G. Kelly,David J. Dr Book 20161st edition S

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FLINT

Post-translational Modificationl modulation of proteins. Posttranslational modifications mediate virtually all cellular processes including cell proliferation, differentiation, apoptosis, and epigenetics in both physiological and pathophysiological conditions. In this chapter, we will summarize the major progresses in this field

焦虑

Epigeneticsamples of these changes include posttranslational modifications to DNA-bound histone proteins, DNA methylation, and remodeling of chromatin architecture. Collectively, epigenetic changes provide a layer of regulation that affects transcriptional activity of genes while leaving DNA sequences unaltere

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cathartic

Hemodynamics During Development and Postnatal Lifeimiting. Hemodynamics is thus not only a key to remodeling of the developing vasculature but also a powerful stimulus for cardiac growth and differentiation. In this chapter are discussed prenatal models of hemodynamic perturbation that help clarifying the role of blood flow in embryogenesis.

geriatrician

https://doi.org/10.1007/978-3-7091-1883-2cardiac malformation; congenital heart disease; genomics; heart development; molecular cardiology; transc

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边缘

Ursula Mense-Petermann,Gabriele WagnerThe heart is a midline structure which is located in the middle, superior, and posterior regions of the mediastinum. Although it is a midline structure of the apex of the heart, normally it is positioned to the left of the midline (Fig. 2.1).

GLEAN

Cardiac Development and Animal Models of Congenital Heart DefectsThe major events of cardiac development, including early heart formation, chamber morphogenesis and septation, as well as conduction system and coronary artery development, are briefly reviewed together with a short introduction to the animal species commonly used to study heart development and model congenital heart defects.