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Titlebook: Congenital Heart Diseases: The Broken Heart; Clinical Features, H Silke Rickert-Sperling,Robert G. Kelly,David J. Dr Book 20161st edition S

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Inflow Tract Development. It involves the creation of two separate atrial chambers, the development of the atrial/atrioventricular septal complex, the processes that lead to the incorporation of the pulmonary venous return to the left atrium, and the incorporation of the caval veins and coronary sinus into the right side o
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Establishment of Cardiac Lateralitys during early embryonic development. Abnormalities in left-right patterning can lead to a variety of congenital heart defects, life-threatening birth defects present in nine out of every one thousand infants born each year in the United States. Recent work has uncovered a highly conserved pathway r
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Evolutionary Aspects of Cardiac Developmentnd molecular biology are making great advances in reconciling these differences by revealing an evolutionarily conserved building plan to the vertebrate heart. This suggests that perspectives from evolution may improve our understanding of the formation of the human heart. Here we exemplify this app
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Cardiac Transcription Factors and Regulatory Networksulatory layers. In this chapter, we first introduce the core cardiac TFs including Gata, Hand, Nkx2, Mef2 and Tbx, and Srf. These factors regulate each other’s expression and also can act in a combinatorial manner on their downstream targets. Their disruption leads to various cardiac phenotypes in m
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