Titlebook: Comparative Genomics; Volume 2 Nicholas H. Bergman Book 2007 Humana Press 2007 DNA.Evolution.Genotyp.Microarray.Nucleotide.SNP.Single Nucle

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Gecko and GhostFamation between the genes contained in such clusters. For a rigorous and efficient detection in multiple genomes, it is essential to have an appropriate model of gene clusters accompanied by efficient algorithms locating them. The Gecko method described herein was designed to serve as a basic tool for

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Genome-wide Copy Number Analysis on GeneChip® Platform Using Copy Number Analyzer for Affymetrix Gen-scale variations in human genomes. This chapter describes methods to analyze copy number alterations in cancer genomes using Affymetrix GeneChip., high-density oligonucleotide microarrays originally developed for large-scale single nucleotide polymorphism (SNP) typing. Combined with the large numbe

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Oligonucleotide Array Comparative Genomic Hybridizationhigh-resolution scale. Here, we present validated protocols using in-house spotted oligonucleotide libraries for array CGH. This oligo array CGH platform yields reproducible results and is capable of detecting single copy gains, multicopy amplifications as well as homozygous and heterozygous deletio

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Studying Bacterial Genome Dynamics Using Microarray-Based Comparative Genomic Hybridizationof genome sequences from closely related strains has uncovered significant differences in gene content, hinting at the dynamic nature of bacterial genomes. The study of these genome dynamics is crucial to leveraging genomic information because the genome sequence of a single bacterial strain may not

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