Titlebook: Co-signal Molecules in T Cell Activation; Immune Regulation in Miyuki Azuma,Hideo Yagita Book 2019 Springer Nature Singapore Pte Ltd. 2019

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Signal Transduction Via Co-stimulatory and Co-inhibitory Receptorsses, via recognition of a specific motif. Consequently, each co-stimulatory receptor transduces a unique pattern of signaling pathways. This review focuses on our current understanding of the intracellular signaling pathways provided by co-stimulatory and co-inhibitory molecules, including B7:CD28 f

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Molecular Dynamics of Co-signal Molecules in T-Cell Activationoves to the cSMAC, CTLA-4 directly accumulates at the cSMAC. PD-1 inhibits activation by inducing dephosphorylation of TCR-upstream signaling molecules by transiently recruiting SHP2, whereas CTLA-4 competes with CD28 for CD80/86 binding within the signaling cSMAC. In general, for both positive and

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Costimulation Blockade in Transplantation pathways can also lead to graft tolerance (Boenisch O, Sayegh MH, Najafian N, Curr Opin Organ Transplant 13:373–378, 2008). However, T-cell costimulation involves an incredibly complex array of interactions that may act simultaneously or at different times in the immune response and whose relative

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Book 2019and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal mole

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