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Titlebook: Co-signal Molecules in T Cell Activation; Immune Regulation in Miyuki Azuma,Hideo Yagita Book 2019 Springer Nature Singapore Pte Ltd. 2019

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Mazharul M. Islam,M. Moazzem Hossainre is no doubt about an importance of co-signal molecules as one of the most promising targets in anti-cancer drugs. However, it should be noted that the proportion of patients who have objective and durable responses to immune checkpoint blockade remains less than 30% in majority of cancers. Thus,
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Control of Regulatory T Cells by Co-signal Moleculeson is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. However, Tregs themselves also depend on many of the same co-signals for their own homeostasis, making this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling in Treg cell biology.
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https://doi.org/10.1007/978-981-32-9717-3Costimulation; Coinhibition; Immune Regulation; CD28; TNF-TNFR; T lymphocytes; Cancer Immunotherapy
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978-981-32-9719-7Springer Nature Singapore Pte Ltd. 2019
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Caroline Wehrmann,Ineke Henze–Rietveldon is derived from their ability to control and restrict the availability of co-signal molecules to other T cells. However, Tregs themselves also depend on many of the same co-signals for their own homeostasis, making this a complex system of feedback. In this chapter, we discuss the critical role of co-signaling in Treg cell biology.
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