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Titlebook: Chronic Myelocytic Leukemia and Interferon; Pathophysiological, Dieter Huhn,Klaus Peter Hellriegel,Norbert Niederl Conference proceedings

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Cytostatic Therapy of Chronic Myelogenous Leukemia: Review and Perspectives, 20, 28, 35, 41]. CML has remained uniformly fatal, and the only curative therapy available up to now has been bone marrow transplantation [16, 58]. This, however, can be offered only to the small proportion of CML patients of sufficiently young age who have an HLA-compatible donor.
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,Konzeption und Beschreibung der Geräte, CML a specific chromosome abnormality, the Philadelphia chromosome (Ph.) (22q-) is present in 90%–95% of patients [2]. The Ph. chromosome results, in most instances, from a balanced reciprocal translocation between chromosome 9 and 22 [t(9;22)] [3].
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Erhard Tietel,Roland Kunkel-van Kaldenkerkenh.-positive cells as assessed by cytogenetic and c-abl/bcr analysis. Thirteen patients failed to show sustained antileukemic response to IFN-gamma. These data demonstrate that the use of IFN-gamma is not effective in inducing hematologic remissions in patients with stable-phase CML in the treatment schedule.
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