Titlebook: Chromosomal Alterations; Methods, Results and Günter Obe,Vijayalaxmi Book 2007 Springer-Verlag Berlin Heidelberg 2007 Aberrationen, chromos

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https://doi.org/10.1007/978-1-4612-1798-5 cells damaged with DSB-inducing agents. The H2A histone variant, H2AX, becomes phosphorylated by the phosphatidylinositol 3-kinase-like protein kinases, ATM and ATR, within 1–3 min after ©-irradiation. The phosphorylated form, called ©-H2AX, can be visualised as discrete foci with the use of specif

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Atmospheric Circulation and Climate,the role of chromatin structure and remodelling in the formation of double-strand breaks and their processing into chromosome damage. Open chromatin conformation, recognized as euchromatin, possesses transcriptional activity, while tighter chromatin conformation, named heterochromatin, remains trans

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Constructing the Export Infrastructure,rial within the cell, preventing its exonucleolytic degradation, end-to-end fusions and other chromosome-lethal events. Interest in this multifunctional chromosome segment has increased considerably since it intervenes in cell senescence, gene transcriptional regulation, premature aging syndromes an

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Structure and Evolution of the Milky Wayto detect SCEs cells must be either treated with the label for one round of replication prior to treatment with the mutagen studied or treated simultaneously, but fixed and harvested following two rounds of replication. Thus, one can never be sure if the label (usually 5-bromo-2′-deoxyuridine, BrdU)

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