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Titlebook: Chromosomal Alterations; Methods, Results and Günter Obe,Vijayalaxmi Book 2007 Springer-Verlag Berlin Heidelberg 2007 Aberrationen, chromos

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书目名称Chromosomal Alterations
副标题Methods, Results and
编辑Günter Obe,Vijayalaxmi
视频video
概述Up-to-date overview on the use of cytogenetics in human population monitoring, in biological dosimetry, in radiation accidents, in astronauts and as a predictive measure of cancer.Written by respected
图书封面Titlebook: Chromosomal Alterations; Methods, Results and Günter Obe,Vijayalaxmi Book 2007 Springer-Verlag Berlin Heidelberg 2007 Aberrationen, chromos
描述.Cytogenetics is a very important research tool in basic and applied research. The uses of cytogenetics in human-population monitoring, in biological dosimetry in radiation accidents and in astronauts and as a predictive measure of cancer are topics discussed in this book. The book will help the reader to better understand cytogenetics and the intricacies of the methodology. The different methods of fluorescence in situ hybridization are discussed and the results achieved are presented. The book provides a comprehensive review of basic and applied aspects of cytogenetics and therefore will be of interest to all who are interested in chromosomes and their alterations by different types of mutagens, including chemical mutagens and ionizing and nonionizing radiation, with special reference to electromagnetic fields..
出版日期Book 2007
关键词Aberrationen, chromosomal; DNA; FISH; Komet Assay; Mikrokerne; Schwesternchromatidenaustausch; Telomere; Vi
版次1
doihttps://doi.org/10.1007/978-3-540-71414-9
isbn_softcover978-3-642-09059-2
isbn_ebook978-3-540-71414-9
copyrightSpringer-Verlag Berlin Heidelberg 2007
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Effects of Ultraviolet Radiation on DNA,tant being pyrimidine dimers and the so-called 6-4-photoproduct. The yield of strand breaks is very low directly after exposure, but they may be formed indirectly upon further incubation. Although DNA absorbs only weakly in the UV-A region, it may be damaged indirectly via endogenous photosensitiser
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Double Strand Break Repair Mechanisms in Mammalian Cells, and repair events or as potentially lethal lesions introduced by ionising radiation or drugs. In any case, DSBs have to be eliminated immediately, because of the recombinogenic capacity of the DNA ends generated by the DSB that increases the risk for undesired chromosomal aberrations (CAs). In orde
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Backup Pathways of Nonhomologous End Joining May Have a Dominant Role in the Formation of ChromosomThey have been directly implicated in cell killing, mutation induction and oncogenic transformation and have spearheaded a great number of investigations focused on their qualitative and quantitative analysis. The central aim of modern cytogenetics is the description at the molecular level of the ob
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Adducts, Sister-Chromatid Exchanges and Mutations Following Benzo[,]pyrene Exposure: a Review of Quion of sister-chromatid exchanges (SCE) and mutations following benzo[.]pyrene (BaP) exposure. Mean adduct levels per dose unit after exposure in vitro were higher in both human (11 studies) and animal (five studies) cells for doses below 5 μM (2.47 and 1.445 adducts per 10. nucleotides per μM, resp
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Comet Assay,n. The comet assay can be applied to all cells, tissues and organs as long as it is possible to generate single cells. The concept of the assay is comparatively simple. In order to study DNA damage either directly after exposure to an agent or after repair has taken place, single cells are placed in
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