Titlebook: Chromosomal Alterations; Methods, Results and Günter Obe,Vijayalaxmi Book 2007 Springer-Verlag Berlin Heidelberg 2007 Aberrationen, chromos

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A Biomedical Perspective of Telomere Structure and Function,rial within the cell, preventing its exonucleolytic degradation, end-to-end fusions and other chromosome-lethal events. Interest in this multifunctional chromosome segment has increased considerably since it intervenes in cell senescence, gene transcriptional regulation, premature aging syndromes an

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Sister-Chromatid Exchanges,to detect SCEs cells must be either treated with the label for one round of replication prior to treatment with the mutagen studied or treated simultaneously, but fixed and harvested following two rounds of replication. Thus, one can never be sure if the label (usually 5-bromo-2′-deoxyuridine, BrdU)

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The CAB and S&S Systems, and an Approach Towards the Classification of Complex Chromosome Exchanges interaction between three or more breaks in two or more chromosomes, i.e. they are actually “complex exchanges”. This is not obvious from the usual solid-staining methods, so nomenclature, scoring systems and theory have developed on the assumption that two-break exchanges are the norm. Such system

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https://doi.org/10.1007/978-3-642-88062-9amaged DNA sites, predominantly damaged bases, single-stand breaks, double-strand breaks and DNA–protein cross-links. Molecular oxygen enhances and thiols reduce the severity of the DNA damage. The mechanisms leading to these lesions are discussed in the light of our present knowledge of the underlying free-radical chemistry.