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Titlebook: Chiral Separations; D. Stevenson,I. D. Wilson Book 1988 Springer Science+Business Media New York 1988 alcohol.amino acid.chemistry.chromat

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发表于 2025-3-21 17:33:38 | 显示全部楼层 |阅读模式
书目名称Chiral Separations
编辑D. Stevenson,I. D. Wilson
视频video
图书封面Titlebook: Chiral Separations;  D. Stevenson,I. D. Wilson Book 1988 Springer Science+Business Media New York 1988 alcohol.amino acid.chemistry.chromat
描述This volume represents the proceedings of a two-day international meeting on chiral chromatography held at the University of Surrey between 3-4 September 1987. The meeting was jointly organized by the Chromatographic SOCiety and the Robens Institute of the University of Surrey in response to the burgeoning interest in this rapid maturing field of chromatography. Nowhere is this interest more evident than in the agrochemical and pharmaceutical industries where the implications of different pharmacological and toxicological activity for the individual enantiomers present in a racemic drug ol" insecticide is an increasing area of concern. Developments in the area of chiral separations are at last beginning to provide SCientists with the necessary tools to study how animals and man handle racemates and relate their obseIVations to the obseIVed biological effects of these substances. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of
出版日期Book 1988
关键词alcohol; amino acid; chemistry; chromatography; cognition; development; drug; drug design; evaluation; fluore
版次1
doihttps://doi.org/10.1007/978-1-4615-6634-2
isbn_softcover978-1-4615-6636-6
isbn_ebook978-1-4615-6634-2
copyrightSpringer Science+Business Media New York 1988
The information of publication is updating

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发表于 2025-3-21 23:55:21 | 显示全部楼层
Drug Analysis using High-Performance Liquid Chromatographic (HPLC) Chiral Stationary Phases: Where situation is reversed. With over 35 commercially available HPLC-CSPs the Chromatograph er has the ability to select an HPLC-CSP to fit the analysis. The problem is how to choose the right one. A possible solution to this problem is a proposed method for the classification of HPLC-CSPs. In this appro
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Book 1988lopment of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of
发表于 2025-3-22 05:35:32 | 显示全部楼层
. The development of robust and Simple methods for the separation of enantiomers will therefore have a profound Impact on safety evaluation and drug design. The meeting proved to be very successful. with over 160 delegates from thirteen countries in Europe and America present to learn from the experiences of 978-1-4615-6636-6978-1-4615-6634-2
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https://doi.org/10.1007/978-94-017-2848-5 to differences in, for example, protein binding, transport, metabolism and clearance. Methods available to determine enantiomers include chromatography on chiral stationary phases, the use of chiral additives in the mobile phase, derivatization to yield diastereoisomers, chiral detectors, NMR and e
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https://doi.org/10.1007/978-94-017-2848-5, diastereomers have different physical properties and can often be easily separated. Using this approach, enantiomers can be resolved through the formation of diastereomeric salts, by the synthesis of diastereomeric derivatives or through the formation of transient diastereomeric complexes. The lat
发表于 2025-3-22 18:53:45 | 显示全部楼层
Sven Koenig,Richard Goodwin,Reid G. Simmons approach used in our development of broad-spectrum chiral stationary phases suitable for liquid chromatographic separation of enantiomers is given. Specific applications are cited, and the logic behind the development of N-aryl alanine-derived phases described, their performances compared, and thei
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发表于 2025-3-23 04:36:44 | 显示全部楼层
Cracking Crosswords: The Computer Challenge,ve been resolved on high performance liquid chromatography by one of two methods, either (i) indirectly, following derivatization, or (ii) directly using chiral stationary phases (Pirkle columns). This latter technique has been used to assess, for example, the stereoselectivity of benzo(a)pyrene (BP
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