Titlebook: Chimera Research; Methods and Protocol Insoo Hyun,Alejandro De Los Angeles Book 2019 Springer Science+Business Media, LLC, part of Springer

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Cancer Stem Cells: Concepts, Challenges, and Opportunities for Cancer Therapyle and facilitate the rational design of CSC-specific therapeutics that would, ideally, have high selectivity for cancer cells, eliminate tumor bulk, and prevent tumor recurrence. Addressing these issues would form some of the key challenges of the CSC research field in the coming years.

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Ethical Considerations in Crossing the Xenobarrierutcomes. Having thus found that no blanket statements can be made on the ethics of chimerization, we examine two important parameters relevant to the ethical evaluation of proposed chimeric research: the argument from moral status and from risk.

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Highly Efficient Derivation of Pluripotent Stem Cells from Mouse Preimplantation and Postimplantatioe polar extreme is naïve pluripotency, which is identified based on the potential to form germline chimeras. At the other polar extreme is primed pluripotency, in which pluripotent cells are primed to differentiate. Mouse naïve PS cells can be derived from preimplantation embryos. Primed epiblast st

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Derivation of Hematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cellsre limited to matched donors, and the availability of umbilical cord blood of immune types. Therefore, derivation of HSCs from patient-specific human induced pluripotent stem cells (hiPSCs) is a holy grail in regenerative medicine. However, derivation of HSCs from iPSCs has proven elusive. Here, the

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Cancer Stem Cells: Concepts, Challenges, and Opportunities for Cancer Therapyture of tumors. First identified in hematological malignancies, CSC populations have to date been proposed in solid tumors in various organs. In vitro and in vivo assays, mouse genetic models, and more recently single-cell sequencing technologies and other ‘-omics’ methodologies have not only facili