Titlebook: Chemical Biology of Nucleic Acids; Fundamentals and Cli Volker A. Erdmann,Wojciech T. Markiewicz,Jan Barci Book 2014 Springer-Verlag Berlin

slow-wave-sleep

MODE

Flexible Nucleobase Analogues: Novel Tools for Exploring Nucleic Acids,leoside scaffold that has only recently garnered attention involves imparting flexibility to the nucleobase instead of the sugar moiety. This flexibility can be achieved by splitting the purine base into its respective imidazole and pyrimidine components or by increasing the number of aromatic rings

Exterior

Sequence-Selective Recognition of Double-Stranded RNA,olecules that bind such double-stranded RNA (dsRNA) selectively and may serve as biochemical probes and potential drug leads has been relatively slow. The surface of dsRNA is relatively uniform, dominated by negatively charged phosphates, and presents little opportunity for the traditional shape-sel

Accrue

prosthesis

fastness

Interregnum

Progress in Chemically Modified Nucleic Acid Aptamers,on systems and produced on a large-scale level at low cost using solid-phase oligonucleotide syntheses. After the methodology of systematic evolution of ligands by exponential enrichment (SELEX) for DNA/RNA aptamer selection was established in the early 1990s, their applications for diagnostic and t

resilience

Aptamers as Molecular Smugglers,ause of their ability to discriminate between different tissues or cell types. If a specific cell type or diseased tissue presents a characteristic marker like a protein, lipid, or sugar on its cell surface, aptamers can be selected that target exclusively this type of cells. The concentrated locali

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破译

Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications,lethora of regulatory RNAs. These RNAs include riboswitches—a class of ligand responsive gene regulating elements—and small RNAs (sRNA)—short RNA or protein targeting sequences. Together, this ensemble of RNAs orchestrates and fine-tunes metabolic, stress response, and virulence pathways. These RNAs