Titlebook: Checkpoint Controls and Cancer; Volume 1: Reviews an Axel H. Schönthal Book 2004 Humana Press 2004

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Cell Cycle Checkpoint Control Mechanisms That Can Be Disrupted in Cancersomes to daughter cells. Understanding the checkpoint pathways and genes involved in the cellular response to DNA damage and cell division events in normal and cancer cells, provides information about cancer predisposition, and suggests design of small molecules and other strategies for cancer thera

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Analysis of Cell Cycle Progression and Genomic Integrity in Early Lethal Knockoutsg to note that recently developed methods to introduce single-copy transgenes into one-cell zygotes via lentiviruses (.) may provide a means to generate Cre/lox-conditional cell lines from these conventional knockouts.

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Methods for Analyzing Checkpoint Responses in ,tosis responses depend on conserved DNA damage checkpoint proteins. Genetics- and genomics-based approaches that have demonstrated roles for conserved checkpoint proteins have also begun to uncover novel components of these response pathways. In this chapter, we will briefly review the . DNA damage

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Statements of Profit and Loss and Cash Flow,ein kinases and several DNA damage checkpoint signaling pathways that inhibit initiation of DNA replication. We provide protocols to prepare cell-free extracts, DNA templates, protein kinase substrates, and to perform checkpoint assays. In addition, we describe related methods that provide useful readouts of the DNA damage response.

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