Titlebook: Central Cholinergic Synaptic Transmission; Michael Frotscher,Ulrich Misgeld Book 1989 Birkhäuser Verlag 1989 Nervous System.Parkinson.anat

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Central nicotinic acetylcholine receptors in the chicken and , CNS: Biochemical and molecular biologx experiments indicate that this membrane protein is different from the toxin-insensitive nAChR present in vertebrate neurons..Crosshybridization with a . nAChR cDNA probe allowed isolation of a cholinergic receptor cDNA (ARD) from the . CNS. Analysis of the corresponding gene, its transcripts and the ARD protein are presented here.

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The Antimicrobial Host Defense of ,pposed to exert an inhibitory influence on the centromedial amygdaloid region. Our data suggest that the amygdaloid nuclei provide a useful model for studies of cholinergic-GABAergic synaptic interconnections in the CNS.

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The Antimicrobial Host Defense of ,Activating rather than depressive effects of Ach were observed on the low voltage-activated component of Ca currents. This effect was also antagonized by atropine but is not mediated by a PTX-sensitive G-protein.

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https://doi.org/10.1007/978-3-642-59674-2ntaining cholinergic neurons and terminals. This lends support to the view detailed in this chapter that the septohippocampal projection is a useful model for studies of cholinergic synaptic mechanisms in the CNS.

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The Antimicrobial Host Defense of , from rat cortex and used this preparation to study transmitter coexistence. Our results indicate that approximately 75% of the cortical cholinergic neurons also express the neuropeptide VIP. Furthermore, we are investigating the expression of Chol-1 in patients affected by diseases such as ALS which primarily involve central cholinergic neurons.

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Direct Visualization of the Cartilagempal neurons (Cole and Nicoll, 1984). Likewise, topical application of acetylcholine (ACh) or analogue drugs to the hippocampus produces sustained paroxysms (Baker and Benedict, 1968). Systemic application of blood-brain-barrier permeant cholinergic drugs produces profound convulsant activity resembling limbic seizures (Turski et al., 1983).