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Titlebook: Cellular and Molecular Aspects of Ageing; Valquiria Bueno Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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Spectra and (Co)homology Theories,n aged organisms, a noticeable reduction in histones levels is accompanied by both local and global chromatin remodeling. This shift creates an imbalance between activating and repressive histone modifications, resulting in widespread transcriptional changes observed in various aging models. Sirtuin
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https://doi.org/10.1007/978-3-540-77751-9ostasis. Adult stem cells (rising from embryonic stem cells) provide a reservoir of cells with capacity to generate somatic cell lineages. Adult stem cells are under control of their microenvironment in the tissue and this region responds to injury, diet, exercise, inflammation, and other factors th
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https://doi.org/10.1007/978-3-540-77751-9rsal phenomenon that affects all living organisms and is characterized by a progressive reduction in both physical and mental capabilities, which is associated with an increased susceptibility to illness and mortality (Viña et al. in IUBMB Life. 59:249–254, 2007; Guo et al. in Signal Transduct Targe
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Spectra and (Co)homology Theories,al of advanced age. Among the causes responsible for the induction of this status, the accumulation of senescent cells in the body play a relevant role. This chapter summarizes the features of senescent cells, how they are induced and maintained in the body and how they can contribute to the develop
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Springer Monographs in Mathematics which senescence is induced, mostly related to stresses inducing some type of DNA damage. Currently, cellular senescence is studied particularly in relation to aging and cancer. Data from animal experiments attribute a key role of cellular senescence in these biological processes, but in humans the
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Introduction,ath. The further understanding of cellular and molecular aspects of ageing could predict the onset of diseases in advance, prevent functional decline and identify targets for interventions focused in healthy ageing. The hypothesis that organismal ageing and dysfunction is influenced by the accumulat
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