Titlebook: Cellular and Molecular Aspects of Ageing; Valquiria Bueno Book 2024 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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Stem Cell Exhaustion,matic stem cells presents decreased number and/or function which has been correlated with deterioration in tissue function and repair. Stem cells are susceptible to DNA damage during quiescent state which leads to stem cells exhaustion due to accumulation of mutations. Moreover, epigenetic modificat

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Spectra and (Co)homology Theories,nication tool between senescent cells and the microenvironment, are also reported, showing that the SASP can be either beneficial or deleterious. Finally, therapeutic interventions with senolytics and senomorphics to counteract the effects of senescent cells and the SASP are summarized.

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Springer Monographs in Mathematicsch could be either beneficial or detrimental. Therefore, considering eliminating senescent cells without any caution may do more harm than good. Much more data are needed in humans to better understand the role of senescent cells and to be able to modulate them for the benefit of the human body.

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Cellular Senescence,ch could be either beneficial or detrimental. Therefore, considering eliminating senescent cells without any caution may do more harm than good. Much more data are needed in humans to better understand the role of senescent cells and to be able to modulate them for the benefit of the human body.