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Titlebook: Cell-Based Assays Using iPSCs for Drug Development and Testing; Carl-Fredrik Mandenius,James A. Ross Book 2019 Springer Science+Business M

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Risks in OTC Derivatives Central Clearingdiscovery projects. Thus far, the use of iPSC-derived cells in small molecule drug screening has been limited, and one of the reasons for this has been the challenge of miniaturization of iPSC culture and differentiation in low volume microwell plate formats. Here we describe a method of seeding iPS
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The Role of OTC Derivatives in the Crisisphagic degradation has been linked to many neurodegenerative diseases and in particular lysosomal storage diseases. Here we describe a high-content assay to detect defects in the autophagy pathway in induced pluripotent stem cell-derived neurons. This assay utilizes immunofluorescence to stain autop
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Oriental Identities in Super-Diverse Britained, while maintaining their endothelial identity. Thus, our differentiation protocol enables the generation of hPSC-derived endothelial cells at a scale that is relevant for drug discovery campaigns or clinical applications.
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Cell-Based Assays Using Differentiated Human Induced Pluripotent Cells,l industry. The joint collaborative effort between academic and pharma partners within the StemBANCC consortium which enabled the implementation of iPSC-derived cellular models for drug discovery is highlighted. This large collaborative scientific network has successfully derived a significant numbe
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Monolayer Generation of Vascular Endothelial Cells from Human Pluripotent Stem Cellse physiologically relevant cell types in a robust and standardized way. Herein, we describe an efficient and scalable monolayer protocol to convert pluripotent stem cells into vascular endothelial cells using defined culture conditions..The combinatorial use of small molecule compounds, growth facto
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