Titlebook: Cell Signal Transduction, Second Messengers, and Protein Phosphorylation in Health and Disease; A. Martin Municio,M. Teresa Miras-Portugal

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Marcks, a Major in Vivo Substrate of Protein Kinase C Purification, Interaction with Model Membranethese enzymes, the identification of physiologically important substrates has received a peculiar attention during the last decade. The myristoylated alanine-rich C kinase substrate (MARCKS) is a widely distributed . and . substrate that has been often used as a marker of the activation of the kinas

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Biochemical and Immunological Characterization of Protein Kinase C Isozymes in Rat Kidney Proximal llowing cascade of events: filtered HCO.- binds a H. to give H.CO.. Proton issued from hydration of cellular CO. is secreted into the tubular fluid (mainly via the apical Na/H antiporter) and combines to filtered HCO.- to give H.CO.. H.CO. is converted into CO. and H.O as rapidly as it is formed, be

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Phospholipid Degradation, Second Messengers and Activation of Cell Signaling Genes, at concentrations down to the picomolar range in a wide variety of cells and tissues (for a review see Braquet et al., 1987). A role for PAF in the nervous system has been suggested by the ability of seizures (Kumar et al., 1988) and certain neurotransmitters (Bussolino et al., 1986; Sogos et al.,

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Platelet-Activating Factor and Calcium Signaling: Its Implication in Cellular Responses, of inositol triphosphate, transiently releases intracellular calcium. This highly sensitive cellular signaling process is involved in a great variety of cellular responses in many organs, and it may play a pivotal role in regulating meditor release in the cell. Through activating phospholipase A.,

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Modulation by Phosphorylation of Microtubule Protein Function in the Development of Neural Processeendrites is indicated.That role is based in the association of MAPs to microtubules. The association of MAPs to microtubules is mainly modulated by phosphorylation and that association regulates the degree of microtubule stability. The presence of stable microtubules correlates with that of cytoplas