Titlebook: Cell Culture Methods for In Vitro Toxicology; Glyn N. Stacey,Alan Doyle,Margherita Ferro Book 2001 Springer Science+Business Media Dordrec

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Intestinal Cell Culture Models,f exposure to xenobiotics from the oral ingestion of therapeutic agents and of environmental pollutants or other additives present in food and water. The intestinal tract is therefore particularly important in toxicology both as a target organ and as a site of access of xenobiotics into the organism

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Cell Culture Models for Neurotoxicology,in, neurons and glial cells. These systems can be used in a two tiered approach, whereby simple cytotoxic models reveal the gross effects of a drug or compound and, subsequently, more complex and subtle assays are used to elucidate the mode of action for the compound of interest (Harvey, 1992; Frazi

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Recombinant Cell Lines for Stress Reporter Assays,hods to replace conventional animal toxicity tests. The ultimate goal is to achieve an alternative system that allows the testing of candidate ingredients, formulations and finished products and to convert the results obtained into accurate predictions of toxic hazard to humans.

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实施生效

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Application of Cell Cultures to Toxicology,ay have a slight but progressive effect on metabolism over a period of hours or longer, and (3) a loss of reproductive potential, e.g. as a result of irradiation, which may not be immediately apparent in a reduction in the viability of the cells.

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Cell Culture Models for Hepatotoxicology,d the hepatocytes, which drains to the lymphatic vessels. At the aposing side of the hepatocyte layers they secrete into the bile canaliculi which collect the cell secretions and transport them to the bile duct. The overwhelmingly predominant cell type performing the majority of liver functions is t

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Book 2001dicated chapters dealwith these issues in a practical way in order to lead the reader tothe right source of information. This book provides an up-to-date,informative and practical review of cell culture methods for .invitro. toxicology. It will be of equal benefit to students andexperienced toxicolo