Titlebook: Cell Culture Methods for In Vitro Toxicology; Glyn N. Stacey,Alan Doyle,Margherita Ferro Book 2001 Springer Science+Business Media Dordrec

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n toxicological studies. It deals with majorcell types studied in the field of toxicology and will be useful foranyone wishing to start work with animal cell cultures or to refreshtheir knowledge relating to .in vitro. cell models. Fundamentalchapters deal with the general biology of cytotoxicity an

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Safety Considerations for , Toxicology Testing,om hazardous chemicals. However, for some materials the level of risk they represent may not be known (a typical situation for many potential carcinogens); the mode of action may be unclear and they may accumulate in the body with long-term exposure.

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Application of Cell Cultures to Toxicology,veral distinct aspects of cytotoxicity, differing in cellular mechanisms, outcome, and, consequently, in the assay of their activity (Freshney, 1904). As requirements for . assays become more demanding, driven by mechanistic studies, economics, and by the desire to reduce animal experimentation, the

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Immortalisation of Primary Cells,and coordinated interaction between cyclins (A-E) and cyclin dependent kinases (for a recent review see Abu-Absi, 2000). ‘Immortalised’ cells escape the normal controls of the cell cycle. Thus, they divide and grow continuously beyond the limits seen in “normal” tissues and primary cells. Historical

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The Drug-Metabolizing Enzymatic System and the Experimental Tools used for , Toxicology for MetabolExposure may occur from food components (i.e. sweeteners, emollients, colorants, emulsifiers, pesticide residues, as well as natural toxicants and byproducts of combustion formed during cooking procedures), from air and water pollutants, from administration of drugs for therapeutic purposes, from th

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