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Titlebook: Cell Culture Methods for In Vitro Toxicology; Glyn N. Stacey,Alan Doyle,Margherita Ferro Book 2001 Springer Science+Business Media Dordrec

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书目名称Cell Culture Methods for In Vitro Toxicology
编辑Glyn N. Stacey,Alan Doyle,Margherita Ferro
视频video
图书封面Titlebook: Cell Culture Methods for In Vitro Toxicology;  Glyn N. Stacey,Alan Doyle,Margherita Ferro Book 2001 Springer Science+Business Media Dordrec
描述.Cell Culture Methods for in vitro Toxicology. introducesthe reader to a range of techniques involved in the use of .invitro. cell culture in toxicological studies. It deals with majorcell types studied in the field of toxicology and will be useful foranyone wishing to start work with animal cell cultures or to refreshtheir knowledge relating to .in vitro. cell models. Fundamentalchapters deal with the general biology of cytotoxicity and cellimmortalisation these are key issues for .in vitro. systemsaddressing the `3Rs‘ principle. Up-to-date overviews deal with the useof cells from liver, brain and intestine. In addition, biochemicalanalysis of cell responses, biotransformation pathways in cells andrecombinant approaches to the early detection of cell stress are alsocovered in detail. .Prominent features of .in vitro. technologies also includeregulation, biosafety and standardisation. Dedicated chapters dealwith these issues in a practical way in order to lead the reader tothe right source of information. This book provides an up-to-date,informative and practical review of cell culture methods for .invitro. toxicology. It will be of equal benefit to students andexperienced toxicolo
出版日期Book 2001
关键词biology; drug; lead; neurotoxicology; pharmacology; research; system; toxicity; toxicology
版次1
doihttps://doi.org/10.1007/978-94-017-0996-5
isbn_softcover978-90-481-5936-9
isbn_ebook978-94-017-0996-5
copyrightSpringer Science+Business Media Dordrecht 2001
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OOPS in real-time control applicationsveral distinct aspects of cytotoxicity, differing in cellular mechanisms, outcome, and, consequently, in the assay of their activity (Freshney, 1904). As requirements for . assays become more demanding, driven by mechanistic studies, economics, and by the desire to reduce animal experimentation, the
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OOPS in real-time control applicationsand coordinated interaction between cyclins (A-E) and cyclin dependent kinases (for a recent review see Abu-Absi, 2000). ‘Immortalised’ cells escape the normal controls of the cell cycle. Thus, they divide and grow continuously beyond the limits seen in “normal” tissues and primary cells. Historical
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