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Titlebook: Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists; Albrecht Fleckenstein,Cornelius Breemen,Friedrich Confer

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Calcium Currents in Mammalian Central Neurones 1980); and Ca-currents have been recorded directly in voltage-clamp experiments on spinal motoneurones (Schwindt and Crill 1980a,b), in hippocampal pyramidal cells (Johnston et al. 1980; Brown and Griffith 1983 b; Halliwell 1983) and in olfactory cortex neurons (A. Constanti and M. Galvan, unpublished observations).
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Ca Entry into Vascular Smooth Musclecontains a regulated Ca. buffer. The evidence for the resting Ca. leak and the excitable Ca. channels as well as that for the regulated buffer was derived from correlations between .Ca influxes and force development in the rabbit aorta.
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Voltage-Dependent Modulation of Cardiac Ca-Channels by Dihydropyridinesrug potency, the results are discussed within the framework of the modulated receptor hypothesis of Hille (1977) and Hondeghem and Katzung (1977) that relates drug-receptor interactions to changes in state of a channel.
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Participation under Tricky Conditions fluxes, particularly across the stimulated myocardial fibre membranes. The present article covers new developments that allow a reliable identification and classification of the drugs which inhibit or promote the Ca. currents specifically, i.e. without concomitant influences on Na.- or Mg. -dependent sarcolemma membrane effects.
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Effects of the Calcium Agonistic Dihydropyridine Bay K 8644 on the Heartpart from offering a new tool for basic research it may introduce a new class of potent positive inotropic drugs. This report is to summarize findings with Bay K 8644 as obtained both in vivo and in vitro with respect to its effects on the heart.
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