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Titlebook: Cardiac Glycosides; Part I: Experimental Kurt Greeff (Direktor) Book 1981 Springer-Verlag Berlin Heidelberg 1981 Drogen.Hormone.Lipid.Respi

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Rubidium Uptake in Erythrocytesd to be inhibited by the cardiac glycosides (c.g.), k-strophanthoside, and digitoxin and their aglucons (., 1953). The drug concentrations necessary to yield this effect ranged from 0.1 µg/ml to 10µg/ml. This effect was shown to be due to an inhibition of membrane Na.-K.-ATPase activity (. et al., 1960; . and ., 1961; ., 1957).
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Radioimmunologic MethodsBased on the work of . and . (1959) on the detection of insulin, radioimmunoassay (RIA) has now developed to be the best and most versatile method for the detection of trace amounts of biologically active substances (hereinafter termed antigens). To enable the detection of an antigen using RIA, the following conditions must be fulfilled
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https://doi.org/10.1007/978-3-658-29782-4and narrow therapeutic range of these compounds. Today, however, digitalis glycosides are indispensable, as there are no other substances known which can increase the contractility of the heart, without increasing but lowering beat frequency, a characteristic of cardiac glycosides which ensures an increase in cardiac efficiency.
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Handbook of Experimental Pharmacologyhttp://image.papertrans.cn/c/image/221780.jpg
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978-3-642-68165-3Springer-Verlag Berlin Heidelberg 1981
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