Titlebook: Cardiac Glycosides; Part I: Experimental Kurt Greeff (Direktor) Book 1981 Springer-Verlag Berlin Heidelberg 1981 Drogen.Hormone.Lipid.Respi

过度

Influence of Cardiac Glycosides on Electrophysiologic Processesy act. With the introduction of new approaches to investigation, such as the voltage clamp technique or ion-selective microelectrodes, considerable progress has been made over the last decade. It is the purpose of this chapter to review the advances made in this field. The scope of this article has

innovation

Influence of Cardiac Glycosides on Myocardial Energy Metabolismwell known clinically that the therapeutic efficiency of these drugs is to a certain degree dependent on the metabolic state of the heart; they are most effective in hearts with no defects in energy metabolism such as congestive heart failure due to excessive hemodynamic pressure loads (e.g., hypert

完成

Effects of Cardiac Glycosides on Na+, K+-ATPase53; see . and ., 1959). Thus, with the discovery of Na ., K.-ATPase (., 1957; . and ., 1957), the effect of these glycosides on the enzyme activity was examined and a specific inhibition was observed (. et al., 1960; ., 1960; see Fig. 1). The interaction of cardiac glycosides with the enzyme, and it

Desert

Influence of Cardiac Glycosides on their Receptorer, generally accepted that their effects are directly on the cardiac cell (for reviews see . and ., 1971; . and ., 1979). A great variety of cellular and subcellular systems has been studied as putative primary points of interaction such as: polymerization of cardiac actin (. et al., 1949), myosin

有说服力

Stimulation and Inhibition of the Na+, K+-Pump by Cardiac Glycosideshe mechanism of this inhibition which paralleled the study of the properties of Na., K.-ATPase (initially described by ., 1957) has allowed us to describe the biochemical mechanism of the Na., K.-pump. Furthermore, the presence of a Na., K.-pump in most of the cells and the multiple functions contro

言外之意

https://doi.org/10.1007/978-3-658-29782-4and narrow therapeutic range of these compounds. Today, however, digitalis glycosides are indispensable, as there are no other substances known which can increase the contractility of the heart, without increasing but lowering beat frequency, a characteristic of cardiac glycosides which ensures an i

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prodrome

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