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Titlebook: Cardiac Glycosides; Part I: Experimental Kurt Greeff (Direktor) Book 1981 Springer-Verlag Berlin Heidelberg 1981 Drogen.Hormone.Lipid.Respi

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书目名称Cardiac Glycosides
副标题Part I: Experimental
编辑Kurt Greeff (Direktor)
视频video
丛书名称Handbook of Experimental Pharmacology
图书封面Titlebook: Cardiac Glycosides; Part I: Experimental Kurt Greeff (Direktor) Book 1981 Springer-Verlag Berlin Heidelberg 1981 Drogen.Hormone.Lipid.Respi
描述Following the monographs by STRAUB (1924) and LENDLE (1935), this is the third contribution to the "Pharmacology of Cardiac Glycosides" within the Handbook of Experimental Pharmacology, which was founded by ARTHUR HEFFTER and con­ tinued by WOLFGANG HEUBNER. Because of the need created by the length of time that had elapsed since LENDLE‘S work, the editorial board requested the rapid ap­ pearance of this 56th volume, which represents current knowledge of the pharma­ cology and clinical pharmacology of cardiac glycosides. In order to avoid any delay, numerous authors were invited to contribute because shorter contributions take less time to prepare and are consequently more up-to-date. The disadvantage is that some overlap between certain chapters could not be avoided, despite the editor‘s efforts. Overlapping can, however, actually be useful, in that differing opinions may be provided and topical issues discussed from varying viewpoints. This re­ minds the reader that scientific horizons in medicine should often be widened or revised. I would like to thank DR. ALANNA Fox and DR. K. ANANTHARAMAN for their help and advice in the revision of certain chapters. I am also grateful to Spr
出版日期Book 1981
关键词Drogen; Hormone; Lipid; Respiration; Steroid; chemistry; chromatography; extraction; oxygen; pharmacokinetics
版次1
doihttps://doi.org/10.1007/978-3-642-68163-9
isbn_softcover978-3-642-68165-3
isbn_ebook978-3-642-68163-9Series ISSN 0171-2004 Series E-ISSN 1865-0325
issn_series 0171-2004
copyrightSpringer-Verlag Berlin Heidelberg 1981
The information of publication is updating

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Chemistry and Structure-Activity Relationships of Cardioactive Steroidsamined repeatedly. The reason for this sustained interest has its roots in the medical use of CAS with the ever-increasing number of the elderly, the narrow therapeutic spectrum, and the wide differences in patient responses to this class of compounds (see this Handbook, Vol. 56/II, Chap. 12). It is
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Use of Radioactively Labeled Glycosidesique. As in the case of other drugs, radioisotope labeled cardiac glycosides offer valuable analytical advantages in the study of absorption, distribution, metabolic breakdown, and elimination. They can be used to measure glycoside concentrations in all forms of biological material. The technique is
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ATPase for the Determination of Cardiac Glycosidesterwards he also found that cardiac glycosides are able to inhibit ATPase activity by binding to the enzyme (., 1960). Extensive work was done by different groups to purify and characterize this enzyme which is specifically associated with active cation transport. Recently the molecular weight of th
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Rubidium Uptake in Erythrocytesd to be inhibited by the cardiac glycosides (c.g.), k-strophanthoside, and digitoxin and their aglucons (., 1953). The drug concentrations necessary to yield this effect ranged from 0.1 µg/ml to 10µg/ml. This effect was shown to be due to an inhibition of membrane Na.-K.-ATPase activity (. et al., 1
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Evaluation of Cardiac Glycosides in the Intact Animaltain guidelines for their therapeutic dosage. Subsequently, as knowledge of the drugs advanced, animal experiments served chiefly to demonstrate and elucidate the actions of the glycosides. More recently, experimental animals have been employed mainly to determine the therapeutic range, intestinal a
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The Use of the Isolated Papillary Muscle for the Evaluation of Positive Inotropic Effects of Cardioaion curve is, at present, the most suitable method (for review see ., 1972). Although isometric contraction curves can, in principle, be obtained from a complete isolated heart contracting against an intraventricular balloon (Fig. 1 b of Chap. 11) as demonstrated by . and . (1910), the use of papill
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