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Titlebook: Cardiac Energy Metabolism in Health and Disease; Gary D. Lopaschuk,Naranjan S. Dhalla Book 2014 Springer Science+Business Media New York 2

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发表于 2025-3-21 19:18:31 | 显示全部楼层 |阅读模式
书目名称Cardiac Energy Metabolism in Health and Disease
编辑Gary D. Lopaschuk,Naranjan S. Dhalla
视频videohttp://file.papertrans.cn/222/221771/221771.mp4
概述Describes the research advances that have been made in understanding what controls cardiac energy metabolism at a molecular, transcriptional and physiological level.Describes how alterations in energy
丛书名称Advances in Biochemistry in Health and Disease
图书封面Titlebook: Cardiac Energy Metabolism in Health and Disease;  Gary D. Lopaschuk,Naranjan S. Dhalla Book 2014 Springer Science+Business Media New York 2
描述.The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease..Cardiac Energy Metabolism in Health and Disease. describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic
出版日期Book 2014
关键词Cardiac energy metabolism; Cardiac ischemia; Cardiomyopathy; Fatty acid oxidation; Mitochondrial functio
版次1
doihttps://doi.org/10.1007/978-1-4939-1227-8
isbn_softcover978-1-4939-4879-6
isbn_ebook978-1-4939-1227-8Series ISSN 2512-2142 Series E-ISSN 2512-2150
issn_series 2512-2142
copyrightSpringer Science+Business Media New York 2014
The information of publication is updating

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发表于 2025-3-21 23:08:02 | 显示全部楼层
Lipoproteins: A Source of Cardiac Lipidshesized in the liver and they obtain their mature form following interaction with enzymes that are present in the circulation. Lipoprotein-derived fatty acids are released by lipoprotein lipase and are then taken up by cardiomyocytes either passively or via fatty acid receptors, such as CD36. Uptake
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Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heartnagement predisposes the patient to heart failure, which is the leading cause of diabetes related deaths. One instigator for this cardiac dysfunction is change in fuel utilization by the heart. Thus, following diabetes, when cardiac glucose utilization is impaired, the heart undergoes metabolic tran
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Control of Myocardial Fatty Acid Uptakel carbohydrate (glucose, lactate) uptake have been unraveled in detail in the 1990s, insight into fatty acid uptake originates from more recent studies. Fatty acid movement across the sarcolemma is facilitated by membrane-associated proteins, specifically CD36, membrane-associated fatty acid-binding
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Relationship Between Substrate Metabolism and Cardiac Efficiencysm with efficient ATP generation and utilization. As ATP is primarily derived from mitochondrial oxidative phosphorylation, myocardial oxygen consumption (MVO.) can be used to measure the rate of energy expenditure of the heart. Although cardiac efficiency is an ambiguous term, it commonly embraces
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The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heartnd energy utilising ATPases. It acts as an energy storage and transport mechanism and maintains favourable local ATP/ADP ratios, thereby supporting further energy production and high levels of free energy from ATP hydrolysis. Down-regulation of CK activity and myocardial creatine levels is a univers
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