Titlebook: Cardiac Energy Metabolism in Health and Disease; Gary D. Lopaschuk,Naranjan S. Dhalla Book 2014 Springer Science+Business Media New York 2

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Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetesterventions that prevent or reverse the energy metabolic switch in the heart of obese and diabetic individuals, and/or the accumulation of fatty acid metabolites may lessen the severity of heart failure. These interventions include inhibiting myocardial fatty acid oxidation, stimulating glucose oxid

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Relationship Between Substrate Metabolism and Cardiac Efficiencythe beneficial effect of metabolic therapies may also relate to improvement of cardiac efficiency. The focus in this chapter will therefore be on our current understanding of how myocardial substrate supply and/or utilization contribute to altered cardiac efficiency.

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Commentary

The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Hearty, however, recent evidence suggests that loss of creatine or CK is not detrimental in surgical models of chronic heart failure, providing the clearest evidence to date that such changes do not contribute to dysfunction. Despite this conclusion, over-expression of CK in mouse heart has been found to

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laceration

Metabolic Therapy for the Ischemic Heartch from one substrate to another according to substrate availability, nutritional status, and exercise level. Paradoxically, during prolonged and severe ischemia the myocardium continues to derive most of its energy (50–70 %) from β-oxidation, despite a high rate of lactate production. At this stage

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Nonparametric Functional Data Analysisprotein lipase (LPL), the enzyme responsible for providing fat to the hearts. Either exaggeration or reduction in its activity following diabetes could lead to heart dysfunction. The objective of this article is to describe the biology of LPL during diabetes. By gaining more insight into the mechani