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Titlebook: Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications; Susan C. Frost,Robert McKenna Book 2014 Springer

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发表于 2025-3-21 17:38:10 | 显示全部楼层 |阅读模式
书目名称Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications
编辑Susan C. Frost,Robert McKenna
视频videohttp://file.papertrans.cn/222/221683/221683.mp4
概述Up to date reference for researchers and students in the carbonic anhydrase family.Contributions from internationally recognized investigators at the forefront of the carbonic anhydrase field.Mix of t
丛书名称Subcellular Biochemistry
图书封面Titlebook: Carbonic Anhydrase: Mechanism, Regulation, Links to Disease, and Industrial Applications;  Susan C. Frost,Robert McKenna Book 2014 Springer
描述The study of carbonic anhydrase has spanned multiple generations of scientists. Carbonic anhydrase was first discovered in 1932 by Meldrum and Roughton. Inhibition by sulfanilamide was shown in 1940 by Mann and Keilin. Even Hans Krebs contributed to early studies with a paper in 1948 showing the relationship of 25 different sulfonamides to CA inhibition. It was he who pointed out the importance of both the charged and uncharged character of these compounds for physiological experiments. The field of study that focuses on carbonic anhydrase (CA) has exploded in recent years with the identification of new families and isoforms. The CAs are metalloenzymes which are comprised of 5 structurally different families: the alpha, beta, gamma, and delta, and epsilon classes. The alpha class is found primarily in animals with several isoforms associated with human disease. The beta CAs are expressed primarily in plants and are the most divergent. The gamma CAs are the most ancient. These are structurally related to the beta CAs, but have a mechanism more similar to the alpha CAs. The delta CAs are found in marine algae and diflagellates. The epsilon class is found in prokaryotes in which it is
出版日期Book 2014
关键词carbonic anhydrase; industrial applications; mechanism; pathology; structure
版次1
doihttps://doi.org/10.1007/978-94-007-7359-2
isbn_softcover978-94-024-0250-6
isbn_ebook978-94-007-7359-2Series ISSN 0306-0225 Series E-ISSN 2542-8810
issn_series 0306-0225
copyrightSpringer Science+Business Media Dordrecht 2014
The information of publication is updating

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发表于 2025-3-21 20:19:49 | 显示全部楼层
Vasile Marinca,Nicolae Herisanuor novel carbonic anhydrase inhibitors. This chapter will highlight the recent and growing interest in carbonic anhydrase inhibitors sourced from nature, demonstrating that natural product chemical space presents a rich source of potential alternate chemotypes for the discovery of novel drug-like carbonic anhydrase inhibitors.
发表于 2025-3-22 01:43:51 | 显示全部楼层
Prokaryotic Carbonic Anhydrases of Earth’s Environmentes decomposing the photosynthate back to CO. thereby closing the global carbon cycle. This review focuses on the physiology and biochemistry of carbonic anhydrases from prokaryotes belonging to the domains . and . that play key roles in the ecology of Earth’s biosphere.
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发表于 2025-3-22 14:11:51 | 显示全部楼层
Dmitry E. Pelinovsky,Aaron Saalmannure and catalytic mechanism of the other CA classes. The overall catalytic site structure and geometry of α-CAs are described in the first section of this chapter followed by the kinetic studies, binding of CO., and the proton shuttle network.
发表于 2025-3-22 19:38:11 | 显示全部楼层
Catastrophe Theory and Economic Dynamics, is discussed. Both antibodies and small molecular weight compounds have been used for targeted imaging of CAIX expression. The use of CAIX expression as an attractive and promising candidate marker for systemic anticancer therapy is also discussed.
发表于 2025-3-22 22:20:44 | 显示全部楼层
Catalytic Mechanism of α-Class Carbonic Anhydrases: CO2 Hydration and Proton Transferure and catalytic mechanism of the other CA classes. The overall catalytic site structure and geometry of α-CAs are described in the first section of this chapter followed by the kinetic studies, binding of CO., and the proton shuttle network.
发表于 2025-3-23 01:29:28 | 显示全部楼层
Carbonic Anhydrase IX as an Imaging and Therapeutic Target for Tumors and Metastases is discussed. Both antibodies and small molecular weight compounds have been used for targeted imaging of CAIX expression. The use of CAIX expression as an attractive and promising candidate marker for systemic anticancer therapy is also discussed.
发表于 2025-3-23 08:54:28 | 显示全部楼层
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