Titlebook: Cannabinoids; Roger G. Pertwee Book 2005 Springer-Verlag Berlin Heidelberg 2005 Cannabinoid.Nervous System.cannabinoid mechanisms of pain

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Structural Requirements for Cannabinoid Receptor Probes, families of endogenous cannabinergic ligands represented by arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol (2-AG), have opened new horizons in this newly discovered field of biology. Furthermore, a considerable number of cannabinoid analogs belonging to structurally diverse classe

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,Cannabinoid Receptors and Their Ligands: Ligand—Ligand and Ligand—Receptor Modeling Approaches,tructural classes of agonists that bind to both receptors, have been identified. An extensive amount of structure-activity relationship information (SAR) has been developed for agonists and antagonists that bind at CB., while the SAR of CB. ligands is only now emerging in the literature. This chapte

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The Phylogenetic Distribution and Evolutionary Origins of Endocannabinoid Signalling,ogenous ligands for these receptors [e.g. anandamide, 2-arachidonoylglycerol (2-AG)] and enzymes involved in the biosynthesis and inactivation of anandamide (e.g. NAPE-PLD, FAAH) and 2-AG (e.g. DAG lipase, MGL). In this review we examine the occurrence of these molecules in non-mammalian organisms (

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Distribution of Cannabinoid Receptors in the Central and Peripheral Nervous System, protein-coupled receptor has a characteristic distribution in the nervous system: It is particularly enriched in cortex, hippocampus, amygdala, basal ganglia outflow tracts, and cerebellum—a distribution that corresponds to the most prominent behavioral effects of cannabis. In addition, this distri

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Effects of Cannabinoids on Neurotransmission,d in axon terminals, and its activation leads to inhibition of transmitter release. The consequence is inhibition of neurotransmission via a presynaptic mechanism. Inhibition of glutamatergic, GABAergic, glycinergic, cholinergic, noradrenergic and serotonergic neurotransmission has been observed in

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Retrograde Signalling by Endocannabinoids,noids), as well as mechanisms for their synthesis, membrane transport and metabolism. Within the brain the marijuana constituent . .-tetrahydrocannabinol (THC) produces its pharmacological actions by acting on cannabinoid CB. receptors. THC modulates neuronal excitability by inhibiting synaptic tran

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Effects on the Immune System,d in vitro. Two modes of action by which .9-tetrahydrocannabinol (THC) and other cannabinoids affect immune responses have been proposed. First, cannabinoids may signal through the cannabinoid receptors CB. and CB.. Second, at sites of direct exposure to high concentrations of cannabinoids, such as

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Imaging of the Brain Cannabinoid System,an be imaged directly with autoradiography in brain slices using radiolabeled cannabinoid receptor ligands. In addition, the effects of pharmacologic doses of unlabeled cannabinoid drugs can be autoradiographically imaged using indicators of blood flow or indicators of metabolism such as glucose ana

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