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Titlebook: Cancer Immunotherapy; Paradigms, Practice Tyler J. Curiel Book 2013 Springer Science+Business Media New York 2013 Anti-tumor immunity.Canc

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Miscellaneous Approaches and Considerations: TLR Agonists and Other Inflammatory Agents, Anti-Chemokdes a broad overview of additional approaches not covered in specific book chapters. Some areas are nonetheless quite advanced, such as the use of TLR agonists in clinical trials, and some have received FDA approvals such as BCG to treat bladder cancer and the IMiD lenalidomide to treat multiple mye
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Monitoring Antigen-Specific Responses in Clinical Trials of Cancer Immunotherapyative parameters of immune function affords the opportunity to identify endpoints that correlate with, or predict clinical benefit and define the requirements for effective therapy. This chapter discusses structural and functional methods to assess both monoclonal and polyclonal antigen-specific T c
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International Political Economy Seriesimprove T cell function and tumor targeting. However many of these strategies come with a price and re-introduce toxicities including death in rare cases. This chapter will outline the development of tumor-specific lymphocyte therapies, highlighting successes and difficulties and discussing potentia
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Modeling the Kinetics of the Immune Responseunctional blockade, differentiation blockade, altering trafficking, differentiation diversion, or raising the threshold of anti-cancer effector cells for Treg-mediated regulation. Several clinical trials have shown the feasibility and relative safety of managing Tregs in human cancer, although treat
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