Titlebook: Cancer Immunotherapy; Paradigms, Practice Tyler J. Curiel Book 2013 Springer Science+Business Media New York 2013 Anti-tumor immunity.Canc

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Historical Perspectives and Current Trends in Cancer Immunotherapy of autoimmunity. These newer understandings caused thinking to evolve and advance. Our rapidly increasing understanding of antitumor immunity and how it can be thwarted has led to new approaches to tumor immunotherapy with great promise to be much more successful than prior generations of approache

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Adoptive T Cell Transferimprove T cell function and tumor targeting. However many of these strategies come with a price and re-introduce toxicities including death in rare cases. This chapter will outline the development of tumor-specific lymphocyte therapies, highlighting successes and difficulties and discussing potentia

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Dendritic Cell-Based Cancer Immunotherapy: Achievements and Novel ConceptsAlthough the evidence on clinical responses is still scarce, expectations are high because the clinical responses that are induced are often long lasting. To improve clinical responses of DC vaccination further, a number of variables are already being tested in clinical trials, including DC maturati

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Peptide and Protein-Based Cancer Vaccinesent knowledge on the promise and pitfalls of defined antigen vaccination strategies for cancer based on synthetic peptides and proteins and discuss novel approaches for combination treatments with novel immunomodulatory agents.

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Managing Regulatory T Cells to Improve Cancer Immunotherapyunctional blockade, differentiation blockade, altering trafficking, differentiation diversion, or raising the threshold of anti-cancer effector cells for Treg-mediated regulation. Several clinical trials have shown the feasibility and relative safety of managing Tregs in human cancer, although treat

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T Cell and Antigen-Presenting Cell Subsets in the Tumor Microenvironment. In this chapter, we review and summarize current knowledge regarding the function, interactions, and prognostic significance of each of these populations, as well as their dependence upon one another within the tumor microenvironment.

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International Political Economy Series. In this chapter, we review and summarize current knowledge regarding the function, interactions, and prognostic significance of each of these populations, as well as their dependence upon one another within the tumor microenvironment.

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