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Titlebook: Cancer Immunotherapy; Paradigms, Practice Tyler J. Curiel Book 2013 Springer Science+Business Media New York 2013 Anti-tumor immunity.Canc

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https://doi.org/10.1007/978-88-470-2571-4igrate to the draining lymph nodes where they can induce an antigen-specific T cell response. A promising strategy to induce a potent, specific, and lasting anti-tumor response is to target tumor antigens to DC in vivo. This represents a clinically generally applicable and cost-effective approach to
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Giorgio Uboldi,Giorgio Cavigliaal tissues and afford a better safety profile compared to nontargeted treatments. Harnessing immune specificity has allowed the successful development of targeted anticancer agents. Successful targeting strategies include antibodies and derivatives, cytokines, peptides, and recombinant viruses. This
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A Process Dedicated to Cognition and Memorydes a broad overview of additional approaches not covered in specific book chapters. Some areas are nonetheless quite advanced, such as the use of TLR agonists in clinical trials, and some have received FDA approvals such as BCG to treat bladder cancer and the IMiD lenalidomide to treat multiple mye
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The New Aesthetic of Data Narrativeative parameters of immune function affords the opportunity to identify endpoints that correlate with, or predict clinical benefit and define the requirements for effective therapy. This chapter discusses structural and functional methods to assess both monoclonal and polyclonal antigen-specific T c
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