Titlebook: Cancer Drug Resistance; Overviews and Method Jose Rueff,António Sebastião Rodrigues Book 2016 Springer Science+Business Media New York 2016

异常

Managing Drug Resistance in Cancer: Role of Cancer Informatics,significant role to interpret this complex data into useful conclusions. In this chapter, the use of bioinformatics platforms, particularly CancerDR, in understanding the cancer drug resistance is described.

元音

Neutron Imaging for Aerospace Applications,o monitor DNA damage and repair capacity as well as the use of clonogenic and β-galactosidase staining assays to assess long-term cell fate after DNA-damaging treatment. Finally, we also present examples of these methods currently used in our laboratory for studying the role of FOXM1 in DNA damage-induced senescence and epirubicin resistance.

注射器

https://doi.org/10.1007/978-0-387-78693-3on transfected cells (e.g., MDCKII-MDR1, MDCKII-MRP2, and MDCKII-BCRP) or cells expressing high amount of intrinsic efflux transporters (Caco-2) utilizing specific inhibitors as positive controls. This chapter presents a method of performing uptake and permeability studies, including the preparation of various buffers required for the study.

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ASSAY

https://doi.org/10.1007/BFb0041485the response to NACT is a valuable indicator of long-term survival. In this work, the advantages and pitfalls of using NAST in BC for studying drug response and resistance for drug development and clinical trials are discussed as well as practical points on how to set up a NAST clinical trial in BC.

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知识

Classical and Targeted Anticancer Drugs: An Appraisal of Mechanisms of Multidrug Resistance,ot only as a consequence of drug therapy but also by apoptosis induced by their microenvironment. Cell death can be mediated by host immune mechanisms and by nonimmune cells acting on so-called death receptors. The tumor cell proliferation rate is also important because it controls tumor regeneratio

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Negotiate

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