Titlebook: Cancer Drug Resistance; Beverly A. Teicher Book 2006 Humana Press 2006 angiogenesis.cancer.cytotoxicity.drug.drug resistance.hormones.imag

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New and Revised Concepts in Multidrug Resistanceen well described in vitro in laboratory models. The extent to which multidrug transporters are responsible for clinical drug resistance has been more difficult to determine. In one sense, P-gp can be viewed as a molecular target that was tested in the clinic before there was an adequate understandi

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Cisplatin Resistanceclinical management of cancers over the last three decades. It is similar to classical alkylating agents, in that the central platinum atom interacts covalently with DNA to also form adducts, which are the cytotoxic lesions. When these adducts are detected by damage recognition proteins, signals are

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Cancer Drug Resistance978-1-59745-035-5Series ISSN 2196-9906 Series E-ISSN 2196-9914

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Cancer Drug Discovery and Developmenthttp://image.papertrans.cn/c/image/221094.jpg

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Gordon J. Kearley,Vanessa K. Petersonlated angiogenesis, instability in perfusion, and hypoxia. Interactions between tumor and endothelial cells occur during tumor growth and in response to therapy. These interactions are of central importance in establishing codependence that contributes to promotion of cell survival, treatment resist

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Materials for the Nuclear Energy Sectorlysis by the tumor cells. In general, the extracellular pH (pHe) in human tumors is below 7.0, whereas the intracellular pH (pHi) is maintained at neutral range, i.e.,>7.0, by powerful pHi control mechanisms. The low pHe and the significant gradients between pHe and pHi affect markedly the response

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Gy. Csom,É. M. Zsolnay,E. J. Szondime aspects of drug resistance, such as the ability to repopulate the tumor mass by clonogenic/stem cell subsets or adhesion/aggregation-dependent changes in responsiveness to therapy may be related to genetic tumor progression, genetic instability, and expression of oncogenic proteins. Combinations

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