Titlebook: Cancer Drug Resistance; Beverly A. Teicher Book 2006 Humana Press 2006 angiogenesis.cancer.cytotoxicity.drug.drug resistance.hormones.imag

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PET Imaging of Response and Resistance to Cancer Therapyochemical and molecular imaging can complement existing in vitro assay methods and is likely to play a key role in early drug testing and development, as well as future clinical practice. Imaging is ideally suited to assessing the spatial and temporal heterogeneity of cancer and to measure in vivo d

Lobotomy

Cancer Stem Cells Implications for Development of More Effective Therapiesble. Recent work has suggested that most, if not all, malignancies are driven by a small subpopulation of cells that have stem cell characteristics. These “tumor stem cells” are thought to arise either from normal tissue stem cells or from early progenitor cells through dysregulation of self-renewal

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Therapeutic Resistance in Leukemiaand collateral sensitivity. These in vivo models have been used for the evaluation of new compounds of potential clinical interest. Crossresistance data coupled with knowledge of the mechanisms of resistance operative in the drug-resistant leukemias may identify useful guides for patient selection f

GLIB

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In Vivo Resistancerug. These tumor lines have been used to extend understanding of drug resistance in a host organism. It is becoming clear as our knowledge of growth factors and cytokines has increased that the proliferation and metabolism of tumor cells, like those of normal cells, are influenced by these naturally

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Leisureliness

The Microenvironment and Drug Resistance microenvironment can significantly affect the success of chemotherapy. The interactions between the tumor cells and their environment can be classified into three main categories: (1) cell-cell contacts, (2) interactions with the extracellular matrix, and (3) interactions with soluble factors/cytok

Osmosis

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Metallothioneins in Drug Resistancec and copper), and some that are both toxic and not required for cell function (for example, cadmium and mercury). A role for MTs in metabolism and detoxication of heavy metals is strongly suggested by the sensitivity of many MT genes to induction by heavy metals and the ability of MT proteins to bi

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