Titlebook: Cancer Drug Resistance; Beverly A. Teicher Book 2006 Humana Press 2006 angiogenesis.cancer.cytotoxicity.drug.drug resistance.hormones.imag

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https://doi.org/10.1007/978-1-4613-2940-4ines. Each of these interactions can influence the sensitivity of the tumor cells to treatment-induced apoptosis and can therefore affect the outcome of therapy. The pathways responsible for these effects are just beginning to be elucidated.

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Per Munck af Rosenschöld M.Sc., Ph.D.dings highlight the importance of these targets in the creation of future novel anticancer drugs. This chapter gives a brief overview of the importance of both GSH and GST in the response to anticancer drug resistance, and highlights some of the anticancer drugs currently being investigated at various stages in the process from lab to clinic.

Apoptosis

Oncogenes and Tumor Suppressor Genes in Therapeutic Resistancenical results. In the not-too-distant future, refinement and commercialization of pharmacogenomic tests in cancer will enable more-accurate predictions regarding responsiveness of individual patients to new and established agents. These data will also enable understanding of pathways of drug resistance and ways to overcome it.

Hypomania

PET Imaging of Response and Resistance to Cancer Therapy have undergone preliminary testing in patients. Examples showing how positron emission tomography imaging can be used to (1) assess the therapeutic target, (2) identify resistance factors, and (3) measure early response are described.

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